Invention Grant
- Patent Title: Use of vista agonists and antagonists to suppress or enhance humoral immunity
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Application No.: US15317552Application Date: 2015-06-11
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Publication No.: US11123426B2Publication Date: 2021-09-21
- Inventor: Kathy A. Green , Li Wang , Randolph J. Noelle , William R. Green
- Applicant: Kathy A. Green , Li Wang , Randolph J. Noelle , William R. Green
- Applicant Address: US NH Lebanon; US VT Norwich; US NH Plainfield; US NH Lebanon
- Assignee: Kathy A. Green,Li Wang,Randolph J. Noelle,William R. Green
- Current Assignee: Kathy A. Green,Li Wang,Randolph J. Noelle,William R. Green
- Current Assignee Address: US NH Lebanon; US VT Norwich; US NH Plainfield; US NH Lebanon
- Agency: Baker, Donelson, Bearman, Caldwell & Berkowitz PC
- Agent Robin L. Teskin
- International Application: PCT/US2015/035371 WO 20150611
- International Announcement: WO2015/191881 WO 20151217
- Main IPC: A61K31/198
- IPC: A61K31/198 ; A61K39/395 ; C07K16/28 ; A61K45/06
Abstract:
Methods for alleviating the suppression of humoral immunity by myeloid-dependent suppressor cells (MDSCs) are provided which include the administration of a VISTA antagonist and an iNOS/NO inhibitor in a subject in need thereof, e.g., subjects with cancer or infectious disease wherein VISTA is aberrantly expressed. This combination has been discovered to elicit a synergistic or additive effect on alleviating suppression of humoral immunity by VISTA which is elicited by MDSCs.
Public/Granted literature
- US20170119877A1 USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY Public/Granted day:2017-05-04
Information query
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