Delta compression method, system and computer program product. Portions of source and target data files are hashed using a hashing function. A target data file is compared against the source data file to determine at least one delta difference between the files. A source data file hashing table is generated. The table includes hashed portions of the source and target data files stored in corresponding source file offset locations and corresponding target file offset locations, respectively. Portions of the source and target files are compared using corresponding source and target file offset locations. At least one common sequence of characters in the portions of the source and target files is determined based on the comparison. A patch file is generated based on the determined sequence of characters.