Systems and methods for dynamically and programmatically controlling hardware and software to optimize bandwidth and latency across partitions in a computing system are discussed herein. In various embodiments, performance within a partitioned computing system may be monitored and used to automatically reconfigure the computing system to optimize aggregate bandwidth and latency. Reconfiguring the computing system may comprise reallocating hardware resources among partitions, programming firewalls to enable higher bandwidth for specific inter-partition traffic, switching programming models associated with individual partitions, starting additional instances of one or more applications running on the partitions, and/or one or more other operations to optimize the overall aggregate bandwidth and latency of the system.