The present disclosure relates to dialysis devices. In some embodiments, a dialysis device may include a disposable housing having a storage chamber in fluid communication with a dialysate flow path. Also included may be a controller, an interface capable of operably coupling the controller and the disposable housing, a fluid displacement structure, a pump configured to actuate a deformable diaphragm, and a pressure sensor to trigger the reversal of the pump. The flow path may be fluidly sealed from the controller and the interface.