Invention Grant
- Patent Title: Methods of treating immune diseases by administering antibody polypeptides that antagonize CD40
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Application No.: US16723047Application Date: 2019-12-20
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Publication No.: US11136406B2Publication Date: 2021-10-05
- Inventor: Anish Suri , Steven Sheriff , Suzanne Suchard , Aaron Yamniuk , Stanley Krystek , James Tamura , James Bryson , Steven Grant , Philip Drew
- Applicant: Bristol-Myers Squibb Company , Domantis Limited
- Applicant Address: US NJ Princeton; GB Middlesex
- Assignee: Bristol-Myers Squibb Company,Domantis Limited
- Current Assignee: Bristol-Myers Squibb Company,Domantis Limited
- Current Assignee Address: US NJ Princeton; GB Middlesex
- Agency: Faegre Drinker Biddle & Reath LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K45/06 ; C07K16/18 ; A61K39/00
Abstract:
Antibody polypeptides that specifically bind a novel epitope of human CD40 are provided. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides are useful in the treatment of diseases involving CD40 activation, such as autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VL or VH domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA).
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