A controller for a building control system includes processors and memory storing instructions that, when executed by the processors, cause the processors to perform operations including identifying zones within a building, analyzing data associated with the zones, and generating zone groupings based on the data associated with the zones. Each of the zone groupings define zone groups and specify which of the zones are grouped together to form each of the zone groups. The operations also include identifying a particular zone grouping from zone groupings based on the data associated with zones and using the particular zone grouping to generate control signals to operate equipment of the building control system to provide heating or cooling to the zones.