Provided are a method, a device, equipment and a storage medium for managing a mobile handover. When the method for managing the mobile handover is applied to a source secondary base station, the method includes: in response to determining to switch a set user equipment (UE) to a target base station, sending a handover request message to the target base station; and in response to receiving a handover request acknowledgement message sent by the target base station, sending a handover command message to the UE by using a signaling radio bearer (SCG SRB) of a source secondary base station side to trigger the UE to perform a random access attempt on a serving cell under the target base station.