Invention Grant
- Patent Title: ASH1L inhibitors and methods of treatment therewith
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Application No.: US16854527Application Date: 2020-04-21
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Publication No.: US11147885B2Publication Date: 2021-10-19
- Inventor: Jolanta Grembecka , Szymon Klossowski , Jing Deng , Tomasz Cierpicki , Hao Li , Hongzhi Miao , Trupta Purohit , EunGi Kim
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones, S.C.
- Agent David W. Staple
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/4545 ; A61K31/454 ; A61K31/404 ; A61K47/64 ; A61K9/00 ; A61K38/45 ; A61P35/02 ; A61K47/54 ; C07D209/24
Abstract:
Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
Public/Granted literature
- US20200246474A1 ASH1L INHIBITORS AND METHODS OF TREATMENT THEREWITH Public/Granted day:2020-08-06
Information query
