Embodiments described include systems and methods for management and pre-establishment of network application and secure communication sessions. Session logs may be analyzed to identify an application or secure communication sessions likely to be accessed, and prior to receiving a request to establish the session, an intermediary (e.g. another device such as an intermediary appliance or other device, or an intermediary agent on a client such as a client application) may pre-establish the session, performing any necessary handshaking or credential or key exchange processes. When the session is subsequently requested (e.g. in response to a user request), the system may immediately begin using the pre-established session. This pre-establishment may be coordinated within the enterprise providing load balancing and scheduling of session establishment to prevent large processing loads at any one point in time.