- 专利标题： Prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells
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申请号： US16990289申请日： 2020-08-11
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公开(公告)号： US11155835B2公开(公告)日： 2021-10-26
- 发明人: Venigalla B. Rao , Jingen Zhu
- 申请人： The Catholic University of America
- 申请人地址： US DC Washington
- 专利权人： The Catholic University of America
- 当前专利权人： The Catholic University of America
- 当前专利权人地址： US DC Washington
- 代理机构： Miles & Stockbridge P.C.
- 代理商 Ajay A. Jagtiani
- 主分类号： C12N15/86
- IPC分类号： C12N15/86
摘要：
Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.
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