Invention Grant
- Patent Title: Fluorescent pH sensors and methods of preparing them
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Application No.: US16479373Application Date: 2018-01-19
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Publication No.: US11156619B2Publication Date: 2021-10-26
- Inventor: Liqiang Zhang , Xiangxing Kong , Yanqing Tian , Deirdre Meldrum , Fengyu Su
- Applicant: Arizona Board of Regents, on behalf of Arizona State University
- Applicant Address: US AZ Scottsdale
- Assignee: Arizona Board of Regents, on behalf of Arizona State University
- Current Assignee: Arizona Board of Regents, on behalf of Arizona State University
- Current Assignee Address: US AZ Scottsdale
- Agency: Byrne Poh LLP
- Agent Nina R. Horan
- International Application: PCT/US2018/014519 WO 20180119
- International Announcement: WO2018/136794 WO 20180726
- Main IPC: G01N21/64
- IPC: G01N21/64 ; G01N33/84 ; C07D471/16 ; C08F220/58 ; C12Q1/02 ; G01N31/22 ; G01N33/50 ; G01N21/77
Abstract:
Fluorescent pH sensors are provided. The fluorescent pH sensor comprises a copolymer for sensing pH and a polymerized form of N-(2-hydroxypropyl)methacrylamide (HPMA) or 2-hydroxyethyl methacrylate (HEMA). The probe for sensing pH has formula (I): wherein R1 and R2 are as defined herein. The fluorescent pH sensors may be used in determining the pH of a sample and detecting extracellular pH in a sample. Methods for preparing the fluorescent pH sensors and the probe for sensing pH are also provided.
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