A configurable spiking neural network based accelerator system is provided. The accelerator system may be executed on an expansion card which may be a printed circuit board. The system includes one or more application specific integrated circuits comprising at least one spiking neural processing unit and a programmable logic device mounted on the printed circuit board. The spiking neural processing unit includes digital neuron circuits and digital, dynamic synaptic circuits. The programmable logic device is compatible with a local system bus. The spiking neural processing units contain digital circuits comprises a Spiking Neural Network that handles all of the neural processing. The Spiking Neural Network requires no software programming, but can be configured to perform a specific task via the Signal Coupling device and software executing on the host computer. Configuration parameters include the connections between synapses and neurons, neuron types, neurotransmitter types, and neuromodulation sensitivities of specific neurons.