Provided is a design method and apparatus for quasi-cyclic low-density parity-check (LDPC) encoding. The method includes: performing LDPC encoding on a K-bit information sequence to be encoded according to a parity check matrix of a quasi-cyclic LDPC code to obtain an N-bit LDPC encoded sequence, where the parity check matrix is determined according to a basic matrix and a lifting size Z, and the basic matrix is determined according to the lifting size Z and a coefficient matrix, where K is a positive integer, N is an integer greater than K, and Z is a positive integer.