A method of transmitting and receiving a signal to and from a user equipment (UE) at a base station supporting full duplex in a wireless communication system includes the base station transmitting a first resource element (RE) set including two REs to the UE by applying different precoders to the two REs of the first RE set, and receiving a second RE set including two REs from a plurality of UEs including the UE while the first RE set is transmitted, by applying different post-coders to the two REs of the second RE set. Code division multiplexing (CDM) codes are applied to the first RE set transmitted from the base station to the UE in downlink and the second RE set transmitted from the UE to the base station in uplink.