Invention Grant
- Patent Title: 2-quinolone derived inhibitors of BCL6
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Application No.: US16616906Application Date: 2018-05-25
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Publication No.: US11161839B2Publication Date: 2021-11-02
- Inventor: Benjamin Richard Bellenie , Kwai Ming Jack Cheung , Owen Alexander Davis , Swen Hoelder , Rosemary Huckvale , Matthew Garth Lloyd
- Applicant: Cancer Research Technology Limited , The Institute of Cancer Research: Royal Cancer Hospital
- Applicant Address: GB London; GB London
- Assignee: Cancer Research Technology Limited,The Institute of Cancer Research: Royal Cancer Hospital
- Current Assignee: Cancer Research Technology Limited,The Institute of Cancer Research: Royal Cancer Hospital
- Current Assignee Address: GB London; GB London
- Agency: Foley Hoag LLP
- Agent David P. Halstead
- Priority: GB1708510 20170526,GB1806131 20180413
- International Application: PCT/GB2018/051444 WO 20180525
- International Announcement: WO2018/215798 WO 20181129
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D401/14 ; C07D471/04 ; C07D471/10 ; C07D491/10 ; C07D405/14 ; C07D401/12 ; A61P35/00

Abstract:
The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: Formula I wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.
Public/Granted literature
- US20210206756A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Public/Granted day:2021-07-08
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