- Patent Title: Bifunctional molecules for degradation of EGFR and methods of use
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Application No.: US16588750Application Date: 2019-09-30
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Publication No.: US11161842B2Publication Date: 2021-11-02
- Inventor: Nathanael Gray , Jaebong Jang , Dries De Clercq , Michael Eck , Pasi Janne
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Lathrop GPM LLP
- Agent Brian C. Trinque
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K47/54 ; A61P35/00 ; A61K47/18

Abstract:
The present application provides bifunctional compounds of Formula (I): which act as protein degradation inducing moieties for EGFR and/or a mutant thereof. The present application also describes methods for the targeted degradation of EGFR and/or a mutant thereof through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to EGFR and/or a mutant thereof which can be utilized in the treatment of disorders modulated by EGFR or a mutant thereof.
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