Invention Grant
![Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof](/docs/US/2021-11-02/US11161854B2/abs.jpg.600x600.jpg)
- Patent Title: Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
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Application No.: US16755172Application Date: 2018-10-08
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Publication No.: US11161854B2Publication Date: 2021-11-02
- Inventor: David Annunziato Candito , Thomas H. Graham , John Acton , Ryan Wing-Kun Chau , Joanna L. Chen , J. Michael Ellis , Peter H. Fuller , Anmol Gulati , Hakan Gunaydin , Solomon Kattar , Mitchell Henry Keylor , Blair T. Lapointe , Ping Liu , Weiguo Liu , Joey L. Methot , Santhosh F. Neelamkavil , Vladimir Simov , Ling Tong , Harold B. Wood
- Applicant: Merck Sharp & Dohme Corp. , David Annunziato Candito , Thomas H. Graham , John Acton , Ryan Wing-Kun Chau , Joanna L. Chen , J. Michael Ellis , Peter H. Fuller , Anmol Gulati , Hakan Gunaydin , Solomon Kattar , Mitchell Henry Keylor , Blair T. Lapointe , Ping Liu , Weiguo Liu , Joey L. Methot , Santhosh F. Neelamkavil , Vladimir Simov , Ling Tong , Harold B. Wood
- Applicant Address: US NJ Rahway; US MA Wrentham; US MA Somerville; US NJ Cranford; US MA Somerville; US MA Braintree; US MA Needham; US MA Ashland; US MA Watertown; US MA Somerville; US MA Wakefield; US MA Malden; US MA Sudbury; US NJ Westfield; US NJ Princeton; US MA Westwood; US NJ Edison; US MA South Boston; US NJ Warren; US NJ Westfield
- Assignee: Merck Sharp & Dohme Corp.,David Annunziato Candito,Thomas H. Graham,John Acton,Ryan Wing-Kun Chau,Joanna L. Chen,J. Michael Ellis,Peter H. Fuller,Anmol Gulati,Hakan Gunaydin,Solomon Kattar,Mitchell Henry Keylor,Blair T. Lapointe,Ping Liu,Weiguo Liu,Joey L. Methot,Santhosh F. Neelamkavil,Vladimir Simov,Ling Tong,Harold B. Wood
- Current Assignee: Merck Sharp & Dohme Corp.,David Annunziato Candito,Thomas H. Graham,John Acton,Ryan Wing-Kun Chau,Joanna L. Chen,J. Michael Ellis,Peter H. Fuller,Anmol Gulati,Hakan Gunaydin,Solomon Kattar,Mitchell Henry Keylor,Blair T. Lapointe,Ping Liu,Weiguo Liu,Joey L. Methot,Santhosh F. Neelamkavil,Vladimir Simov,Ling Tong,Harold B. Wood
- Current Assignee Address: US NJ Rahway; US MA Wrentham; US MA Somerville; US NJ Cranford; US MA Somerville; US MA Braintree; US MA Needham; US MA Ashland; US MA Watertown; US MA Somerville; US MA Wakefield; US MA Malden; US MA Sudbury; US NJ Westfield; US NJ Princeton; US MA Westwood; US NJ Edison; US MA South Boston; US NJ Warren; US NJ Westfield
- Agent Sylvia A. Ayler; Catherine D. Fitch
- International Application: PCT/US2018/054789 WO 20181008
- International Announcement: WO2019/074809 WO 20190418
- Main IPC: C07D491/10
- IPC: C07D491/10 ; C07D401/14 ; C07D403/04 ; C07D403/14 ; C07D405/14 ; C07D413/14 ; C07D487/08 ; C07D498/04 ; C07D498/10 ; C07D519/00
![Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof](/abs-image/US/2021/11/02/US11161854B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to substituted certain reversed indazolyl-spiro[2.2]pentane-carbonitrile derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
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