A system for evaluating health-related quality of life (HRQOL) can include a sensor adapted to generate sensor data for a user, a memory adapted to store the sensor data, and a processor coupled to the sensor and the memory. The processor can be configured to initiate executable operations including determining a first biological marker for the user from the sensor data, wherein the first biological marker is indicative of a first dimension of HRQOL, performing speech analysis on user provided speech to determine a second biological marker indicative of a second dimension of HRQOL. The processor is further configured to initiate executable operations including comparing the first biological marker and the second biological marker with a baseline for the first biological marker and a baseline for the second biological marker, respectively, and outputting a result of the comparing.