Invention Grant
- Patent Title: Method and system for assisting pathologist identification of tumor cells in magnified tissue images
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Application No.: US16488029Application Date: 2017-02-23
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Publication No.: US11170897B2Publication Date: 2021-11-09
- Inventor: Martin Christian Stumpe , Lily Peng , Yun Liu , Krishna K. Gadepalli , Timo Kohlberger
- Applicant: Google LLC
- Applicant Address: US CA Mountain View
- Assignee: Google LLC
- Current Assignee: Google LLC
- Current Assignee Address: US CA Mountain View
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/US2017/019051 WO 20170223
- International Announcement: WO2018/156133 WO 20180830
- Main IPC: G16H50/20
- IPC: G16H50/20 ; G06T7/11 ; G16H30/40 ; G06K9/62 ; G06T7/00 ; G06T11/00 ; G01N33/483

Abstract:
A method, system and machine for assisting a pathologist in identifying the presence of tumor cells in lymph node tissue is disclosed. The digital image of lymph node tissue at a first magnification (e.g., 40×) is subdivided into a multitude of rectangular “patches.” A likelihood of malignancy score is then determined for each of the patches. The score is obtained by analyzing pixel data from the patch (e.g., pixel data centered on and including the patch) using a computer system programmed as an ensemble of deep neural network pattern recognizers, each operating on different magnification levels of the patch. A representation or “heatmap” of the slide is generated. Each of the patches is assigned a color or grayscale value in accordance with (1) the likelihood of malignancy score assigned to the patch by the combined outputs of the ensemble of deep neural network pattern recognizers and (2) a code which assigns distinct colors (or grayscale values) to different values of likelihood of malignancy scores assigned to the patches.
Public/Granted literature
- US20200066407A1 Method and System for Assisting Pathologist Identification of Tumor Cells in Magnified Tissue Images Public/Granted day:2020-02-27
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