Disclosed herein are a server apparatus, a client apparatus, and a method for communication based on network address mutation. The method for communication based on network address mutation, performed by the server apparatus and the client apparatus, includes setting the external address of a network interface for receiving a packet from the client apparatus; setting the internal address of a hidden interface in order to forward the packet received through the network interface to the hidden interface; modifying the external address based on a preset network address mutation rule; and communicating with the client apparatus by forwarding the packet, received from the client apparatus based on the modified external address, to the hidden interface.