Invention Grant
![2-[4-(meihylaminomethyl)phenyl]-5-fluoro- benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof](/docs/US/2021-11-16/US11174237B2/abs.jpg.600x600.jpg)
- Patent Title: 2-[4-(meihylaminomethyl)phenyl]-5-fluoro- benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof
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Application No.: US16623297Application Date: 2018-05-31
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Publication No.: US11174237B2Publication Date: 2021-11-16
- Inventor: Chunhao Yang , Zehong Miao , Cun Tan , Xiajuan Huan , Jian Ding , Yi Chen
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD.
- Applicant Address: CN Shanghai; CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD.
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD.
- Current Assignee Address: CN Shanghai; CN Shanghai
- Agency: Novick, Kim & Lee, PLLC
- Agent Bin Lu; Zhi Yang Xue
- Priority: CN201710449281.2 20170614
- International Application: PCT/CN2018/089222 WO 20180531
- International Announcement: WO2018/228205 WO 20181220
- Main IPC: C07D307/84
- IPC: C07D307/84
![2-[4-(meihylaminomethyl)phenyl]-5-fluoro- benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof](/abs-image/US/2021/11/16/US11174237B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs.
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