The present invention discloses a touch display driving device and a driving method in the same. The touch display driving device is used for driving a touch display panel, the touch display panel comprising a plurality of common electrode blocks and a plurality of display regions. The touch display driving device comprising a multiplexing circuit which is configured to: during a display period, couple one or more common electrode blocks corresponding to one of the display regions which is to be displayed during the display period to a first voltage; and during the display period, couple one or more of the common electrode blocks corresponding to the display regions which are not to be displayed during the display period to a second voltage.