Embodiments of the present disclosure provide a pixel arrangement structure, a display panel, and a display device. The pixel arrangement structure includes at least one repeating pixel group, wherein each of the at least one repeating pixel group includes a first pixel unit, a second pixel unit, a third pixel unit, and a fourth pixel unit. Two sub-pixels of the first pixel unit are adjacent to two sub-pixels of the second pixel unit, and two sub-pixels of the third pixel unit are adjacent to two sub-pixels of the fourth pixel unit, thereby achieving pixel multiplexing.