Disclosed are various examples for threat detection and security for edge devices in communication with Internet-of-Things (IoT) devices. In one example, a profile is associated with a virtual machine of a gateway device. The profile includes an expected behavior for the virtual machine. The virtual machine is executed by a hypervisor of the gateway device. An actual behavior for the virtual machine is determined. A remedial action is performed. The remedial action is based on an anomaly between the expected behavior and the actual behavior.