Invention Grant
- Patent Title: Combinations of mRNAs encoding immune modulating polypeptides and uses thereof
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Application No.: US16543102Application Date: 2019-08-16
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Publication No.: US11185510B2Publication Date: 2021-11-30
- Inventor: Joshua P. Frederick , Ailin Bai , Vladimir Presnyak , Stephen G. Hoge , Kerry Benenato , Iain McFadyen , Ellalahewage Sathyajith Kumarasinghe , Susannah Hewitt
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Cooley LLP
- Agent Amy E. Mandragouras; Ariana D. Harris
- Main IPC: A61K38/20
- IPC: A61K38/20 ; A61K9/51 ; A61K48/00 ; A61K38/17 ; A61K9/00 ; A61K39/39 ; A61K45/06 ; A61K9/127 ; C07K14/54 ; C07K14/545 ; C07K14/705 ; A61K31/7088 ; A61K31/7115 ; A61P35/00 ; A61K39/395 ; A61K39/00 ; B82Y5/00 ; C12N15/88
Abstract:
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Information query
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