Provided are a screen frame and a laser projection display device. The screen frame includes a plurality of side frames that are connected end to end, where each two adjacent side frames of the plurality of side frames are connected by at least two connectors, and the at least two connectors are connected to the each two adjacent side frames by fasteners; the at least two connectors include a first connector and a second connector, and an inserting direction of a fastener on the first connector is perpendicular to a plane where the screen frame is located, and an inserting direction of a fastener on the second connector is parallel to the plane where the screen frame is located. The present disclosure can realize accurate alignment and joining relatively easily.