Invention Grant
- Patent Title: Diazaspiro ROCK inhibitors
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Application No.: US16760682Application Date: 2018-11-01
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Publication No.: US11192891B2Publication Date: 2021-12-07
- Inventor: Yeheng Zhu , Sunita V. Dewnani , William R. Ewing
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2018/058611 WO 20181101
- International Announcement: WO2019/089868 WO 20190509
- Main IPC: C07D471/10
- IPC: C07D471/10 ; A61K31/438 ; A61K9/00 ; C07D487/10

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Public/Granted literature
- US20210188848A1 DIAZASPIRO ROCK INHIBITORS Public/Granted day:2021-06-24
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