![Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt](/docs/US/2021-12-07/US11192896B2/abs.jpg.600x600.jpg)
- 专利标题： Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt
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申请号： US17318772申请日： 2021-05-12
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公开(公告)号： US11192896B2公开(公告)日： 2021-12-07
- 发明人: Christopher K. Murray , Leonard W. Rozamus , John J. Chaber , Pradeep K. Sharma
- 申请人： ARIAD Pharmaceuticals, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： ARIAD Pharmaceuticals, Inc.
- 当前专利权人： ARIAD Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
![Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt](/abs-image/US/2021/12/07/US11192896B2/abs.jpg.150x150.jpg)
摘要：
Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.
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