A method for design optimization of a quantum circuit includes analyzing a first quantum circuit design based on at least one of a set of design criteria, wherein the first quantum circuit design includes a set of quantum logic gates, and wherein a design criterion in the set of design criteria includes changing a size of a matrix of transformations corresponding to a number of qubits employed in the first quantum circuit design. The embodiment further includes in the method modifying the first quantum circuit design into a transformed quantum circuit design, the modifying causing the transformed quantum circuit design to perform an operation implemented in the first quantum circuit design with a changed matrix of transformations.