Provided is a tablet guiding path adjusting apparatus that adjusts a tablet guiding path adjusting mechanism in the tablet cassette, comprising a rotor rotatably equipped within a cassette body and having a tablet guiding path for receiving at least one of tablets received within the cassette body and guiding to a discharging orifice of the cassette body; a partition member for entering the tablet guiding path and being located between a tablet at the lowest part and a tablet at the upper side thereof; and tablet guiding paths adjusting mechanisms configured to adjust at least either dimension of the depth and width of the tablet guiding path to the rotor; wherein the tablet guiding path adjusting apparatus engages with engaging parts of the tablet guiding path adjusting mechanisms to operate the tablet guiding path adjusting mechanism, and adjusts a dimension of the tablet guiding path in accordance with the shape or size of tablets received within the cassette body.