Systems and methods described herein provide a centralized solution for interference mitigation that focuses on efficient spectrum management. Wireless Access Points (APs) collect interference measurements for wireless channels and generate corresponding interferer airtime estimates. The APs also determine Packet Error Rates (PERs) for wireless client devices currently being served via the channels by the APs. The APs send the interferer airtime measurements and the PERs to a centralized controller. If an interferer airtime estimate and a PER for a particular channel satisfy predefined threshold conditions, the controller modifies an allocation of wireless bandwidth for an AP that is currently using the channel and sends a message to the AP indicating how the allocation has been modified.