A wireless patient monitoring device can be fully functional stand-alone patient monitoring device capable of various physiological measurements. The patient monitoring device is small and light enough to be comfortably worn on the patient, such as on the patient's wrist or around the neck. The patient monitoring device can have a monitor instrument removably engaging a disposable base. The base can have outlets for connecting to an acoustic respiration sensor and an oximeter sensor. The patient monitoring device can have pogo pin connectors connecting the monitor instrument and the disposable base so that the monitor instrument can receive sensor data from the sensors connected to the disposable base.