A method and device for sending and receiving a preamble sequence of a physical random access channel, comprising: scrambling a preamble subsequence and then sending, the preamble subsequence being scrambled according to a cyclic shift value of a preamble subsequence sent in the previous stage; performing a descrambling operation according to a cyclic shift value of a preamble subsequence received in the previous stage during reception; and determining a preamble sub-sequence detected after descrambling as a preamble sub-sequence received in the current stage, where the received preamble sub-sequence in the current stage and the received preamble sub-sequence in the previous stage belong to the same preamble sequence.