- 专利标题： Emetine compounds for treatment and prevention of flavivirus infection
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申请号： US16718343申请日： 2019-12-18
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公开(公告)号： US11207315B2公开(公告)日： 2021-12-28
- 发明人: Hengli Tang , Emily M. Lee , Anil Mathew Tharappel , Hongjun Song , Guo-Li Ming , Wei Zheng , Miao Xu , Shu Yang , Ruili Huang , Wenwei Huang , Khalida Shamim , Hao Li
- 申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , THE JOHNS HOPKINS UNIVERSITY , The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US FL Tallahassee; US MD Baltimore; US MD Bethesda
- 专利权人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.,THE JOHNS HOPKINS UNIVERSITY,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.,THE JOHNS HOPKINS UNIVERSITY,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US FL Tallahassee; US MD Baltimore; US MD Bethesda
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 主分类号： A61K31/4745
- IPC分类号： A61K31/4745 ; A61K45/06 ; A61P31/14
摘要：
The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as dengue virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as dengue virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such dengue virus infections.
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