Invention Grant
- Patent Title: Substituted indole Mcl-1 inhibitors
-
Application No.: US16688872Application Date: 2019-11-19
-
Publication No.: US11208415B2Publication Date: 2021-12-28
- Inventor: Taekyu Lee , Zhiguo Bian , Johannes Belmar , Plamen P. Christov , Nicholas F. Pelz , Subrata Shaw , Kwangho Kim , James C. Tarr , Edward T. Olejniczak , Bin Zhao , Stephen W. Fesik
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D403/14 ; C07D209/42 ; A61K31/551 ; A61K31/381 ; A61K31/4045 ; A61K31/498 ; C07D409/14 ; C07D471/04 ; C07D409/12 ; A61K31/404 ; A61K31/4155 ; A61K31/4439 ; A61K31/454 ; A61K31/4725 ; A61K31/496 ; A61K31/4985 ; A61K31/5377 ; A61K45/06 ; C07D401/14 ; C07D403/12 ; C07D405/12 ; C07D405/14
Abstract:
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Information query
