- 专利标题： Anti-KRAS-G12D T cell receptors
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申请号： US16838395申请日： 2020-04-02
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公开(公告)号： US11208456B2公开(公告)日： 2021-12-28
- 发明人: Eric Tran , Yong-Chen Lu , Anna Pasetto , Paul F. Robbins , Steven A. Rosenberg , Zhili Zheng
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Leydig, Voit & Mayer
- 主分类号： C07K14/82
- IPC分类号： C07K14/82 ; A61P35/00 ; A61K38/00 ; C12N15/85 ; C07K14/725 ; G01N33/574
摘要：
Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
公开/授权文献
- US20200247869A1 ANTI-KRAS-G12D T CELL RECEPTORS 公开/授权日：2020-08-06
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