- 专利标题： IncRNAs GADLOR 1 and 2 for use in treating and preventing cardiac remodelling
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申请号： US16616398申请日： 2018-05-30
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公开(公告)号： US11208656B2公开(公告)日： 2021-12-28
- 发明人: Jörg Heineke , Natali Froese
- 申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
- 申请人地址： DE Hannover
- 专利权人： MEDIZINISCHE HOCHSCHULE HANNOVER
- 当前专利权人： MEDIZINISCHE HOCHSCHULE HANNOVER
- 当前专利权人地址： DE Hannover
- 代理机构： Grant IP, Inc.
- 优先权： EP17173818 20170531
- 国际申请： PCT/EP2018/064226 WO 20180530
- 国际公布： WO2018/220038 WO 20181206
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; C12Q1/68
摘要：
The present invention relates to a compound inhibiting the expression and/or the activity of a long non-coding RNA (lncRNA) selected from GADLOR 1 and GADLOR 2 for use in treating or preventing cardiac remodelling, wherein GADLOR 1 comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs 1 to 3 and sequences being at least 75% identical thereto, and GADLOR 2 comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs 4 to 6 and sequences being at least 75% identical thereto.
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