Imaging systems and methods are disclosed that use multiple illumination pulses to irradiate a scene of interest. An example system includes optics to receive a sequence of returned light pulse portions scattered or reflected from the scene. A modulator is configured to modulate the intensity of the returned light pulse portions to form a sequence of modulated light pulse portions. A means of selectively exposing a sensor during a sequence of exposure periods is also included, so that each modulated light pulse portion is received by the sensor during one of the exposure periods, respectively. The sensor is configured to generate a sequence of sensor signals as a result of receiving the modulated light pulse portions and to accumulate the sensor signals to form a sensor output signal. A processor may read the sensor output signal and process the image based on that signal.