A video stream switching method includes receiving, by transmission device, a plurality of video streams of a first video and a plurality of video streams of a second video, sending the video streams of the first video through target output ports respectively corresponding to the video streams of the first video, after receiving a switching instruction, determining switching reference information of a reference end-of-frame packet of each video stream of the first video and the second video, determining switching reference information of a switching packet of the video stream, and switching from the video streams of the first video to the video streams of the second video based on the switching reference information of the switching packet of each video stream.