A gray-level compensation method and apparatus, a display device and a computer storage medium are provided, which belong to the field of display technology. The method includes: acquiring an initial gray-level value of a target pixel; determining an actual luminance offset of the target pixel based on the initial gray-level value, where different initial gray-level values within a specified threshold range correspond to different actual luminance offsets; and performing a gray-level compensation on the target pixel based on the actual luminance offset. The actual luminance offset is determined based on the initial gray-level value of the target pixel, and since the different initial gray-level values within the specified threshold range correspond to the different actual luminance offsets, flexibility of gray-level compensation performed on the pixel is improved.