An inflator-based system provides for the actuation of valves and other devices using automotive air bag inflators, for example. One or more inflators can be connected to a valve body with an adapter such that upon inflator activation, inflator gases can act on a piston or similar device to achieve desired movement or operation of the valve or device. An inflator-based actuator can provide for a single action or multiple actions of a valve or other device. Such a system can provide safer and more reliable alternatives to electro-explosive ordnance devices found in pyrovalves, for example. Other uses for an inflator-based actuation system can include a lanyard pull initiator, a dual cartridge cutter, a bolt cutter, a hot gas generator (HGG) body, and a HGG pressure cartridge, to name a few examples.