A device and method are described for transmitting tissue conductance communication (TCC) signals. A device may be is configured to establish a transmission window by transmitting a TCC test signal at multiple time points over a transmission test period to a receiving device and detect at least one response to the transmitted TCC test signals performed by the receiving device. The IMD is configured to establish the transmission window based on the at least one detected response so that the transmission window is correlated to a time of relative increased transimpedance between a transmitting electrode vector and receiving electrode vector during the transmission test period.