A method and system for measuring and controlling cross-link interference (CLI) between two devices in a wireless communication network is disclosed herein. In one embodiment, a method implemented on a first node for mitigating CLI between the first node and a second node is disclosed. The method comprises: receiving a wireless signal from the second node; measuring the wireless signal to determine a measurement value according to a predetermined metric for measuring CLI; determining an event based on the measurement value; and mitigating the CLI in accordance with a predetermined mitigation scheme associated with the event.