- 专利标题： Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multiforme and medulloblastoma
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申请号： US16242752申请日： 2019-01-08
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公开(公告)号： US11234955B2公开(公告)日： 2022-02-01
- 发明人: Dennis M. Brown , Jeffrey Bacha , Sandra Dunn
- 申请人： Del Mar Pharmaceuticals (BC) Ltd.
- 申请人地址： CA Vancouver
- 专利权人： Del Mar Pharmaceuticals (BC) Ltd.
- 当前专利权人： Del Mar Pharmaceuticals (BC) Ltd.
- 当前专利权人地址： CA Vancouver
- 代理机构： Christensen O'Connor Johnson Kindness PLLC
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; G01N33/50 ; A61K31/336 ; A61K31/495 ; A61K31/047 ; C12Q1/6886 ; A61K47/54 ; A61K47/59 ; A61K47/62 ; A61K31/4188 ; A61K45/06 ; A61N5/10
摘要：
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.