Invention Grant
- Patent Title: Method for identifying modulators of G3BP activity
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Application No.: US16453313Application Date: 2019-06-26
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Publication No.: US11237168B2Publication Date: 2022-02-01
- Inventor: J. Paul Taylor , Peiguo Yang , Wenwei Lin , Taosheng Chen
- Applicant: St. Jude Children's Research Hospital
- Applicant Address: US TN Memphis
- Assignee: St. Jude Children's Research Hospital
- Current Assignee: St. Jude Children's Research Hospital
- Current Assignee Address: US TN Memphis
- Agency: Licata & Tyrrell P.C.
- Main IPC: G01N21/64
- IPC: G01N21/64 ; G01N33/573
Abstract:
A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).
Information query
