Invention Grant
- Patent Title: N-substituted indole derivatives as PGE2 receptor modulators
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Application No.: US15777597Application Date: 2016-11-17
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Publication No.: US11241431B2Publication Date: 2022-02-08
- Inventor: Heinz Fretz , Isabelle Lyothier , Julien Pothier , Sylvia Richard-Bildstein , Thierry Sifferlen , Lorenza Wyder Peters , Davide Pozzi , Olivier Corminboeuf
- Applicant: Idorsia Pharmaceuticals Ltd
- Applicant Address: CH Allschwil
- Assignee: Idorsia Pharmaceuticals Ltd
- Current Assignee: Idorsia Pharmaceuticals Ltd
- Current Assignee Address: CH Allschwil
- Agency: Hoxie & Associates LLC
- Priority: WOPCT/EP2015/077269 20151120
- International Application: PCT/EP2016/078028 WO 20161117
- International Announcement: WO2017/085198 WO 20170526
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61P35/00 ; A61K45/06 ; C07D403/12 ; C07D403/14 ; C07D413/14 ; C07D417/14
Abstract:
The present invention relates to derivatives of formula (I) wherein (R1)n, R2, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
Public/Granted literature
- US20200289507A1 N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS Public/Granted day:2020-09-17
Information query
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