A system and method for efficient virtual machine memory monitoring with hyper-threading includes executing, by a hypervisor executing on a plurality of physical processors, a virtual central processor unit (VCPU) of a virtual machine on a first hyper-thread. The plurality of physical processors include a first physical processor having the first hyper-thread and a second hyper-thread. The virtual machine executes on the first hyper-thread. Then, the second hyper-thread executes a memory monitoring instruction on a designated range of a shared memory to cause the second hyper-thread to stop executing. Then, a guest in the virtual machine updates the designated range of the shared memory by storing a first request in the designated range of the shared memory to wake up the second hyper-thread.