- 专利标题: Inhibiting ubiquitin specific peptidase 30
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申请号: US16753439申请日: 2018-10-05
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公开(公告)号: US11247987B2公开(公告)日: 2022-02-15
- 发明人: Justin Caravella , Bingsong Han , Cuixian Liu , Stephanos Ioannidis , Alexandre Joseph Buckmelter , David James Richard , Matthew W. Martin , Steven Mischke , Scot Mente
- 申请人: FORMA Therapeutics, Inc.
- 申请人地址: US MA Watertown
- 专利权人: FORMA Therapeutics, Inc.
- 当前专利权人: FORMA Therapeutics, Inc.
- 当前专利权人地址: US MA Watertown
- 代理机构: Choate, Hall & Stewart LLP
- 代理商 John P. Rearick; Erica M. D'Amato
- 国际申请: PCT/US2018/054520 WO 20181005
- 国际公布: WO2019/071073 WO 20190411
- 主分类号: C07D417/04
- IPC分类号: C07D417/04 ; C07D417/12 ; C07C261/04 ; C07D231/40 ; C07D241/04 ; C07D265/30 ; C07D277/46 ; C07D277/56
摘要:
The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Protease 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical entities as disclosed herein can be useful in the treatment of a disease, disorder, or condition involving mitochondrial dysfunction, including neurodegenerative diseases, motor neuron diseases, metabolic disorders, and cancers, among other ailments. Chemical entities disclosed herein include compounds of Formula (II): wherein A, R2, R3, R4, Ra, Rc, Rd, Re, Rf, and m are defined herein.
公开/授权文献
- US20200317658A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 公开/授权日:2020-10-08
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