Invention Grant
- Patent Title: Inhibiting ubiquitin specific peptidase 30
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Application No.: US16753439Application Date: 2018-10-05
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Publication No.: US11247987B2Publication Date: 2022-02-15
- Inventor: Justin Caravella , Bingsong Han , Cuixian Liu , Stephanos Ioannidis , Alexandre Joseph Buckmelter , David James Richard , Matthew W. Martin , Steven Mischke , Scot Mente
- Applicant: FORMA Therapeutics, Inc.
- Applicant Address: US MA Watertown
- Assignee: FORMA Therapeutics, Inc.
- Current Assignee: FORMA Therapeutics, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Choate, Hall & Stewart LLP
- Agent John P. Rearick; Erica M. D'Amato
- International Application: PCT/US2018/054520 WO 20181005
- International Announcement: WO2019/071073 WO 20190411
- Main IPC: C07D417/04
- IPC: C07D417/04 ; C07D417/12 ; C07C261/04 ; C07D231/40 ; C07D241/04 ; C07D265/30 ; C07D277/46 ; C07D277/56

Abstract:
The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Protease 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical entities as disclosed herein can be useful in the treatment of a disease, disorder, or condition involving mitochondrial dysfunction, including neurodegenerative diseases, motor neuron diseases, metabolic disorders, and cancers, among other ailments. Chemical entities disclosed herein include compounds of Formula (II): wherein A, R2, R3, R4, Ra, Rc, Rd, Re, Rf, and m are defined herein.
Public/Granted literature
- US20200317658A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 Public/Granted day:2020-10-08
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