- Patent Title: Fusion proteins comprising a non-cytotoxic protease, a translocation domain, and a targeting moiety that binds a galanin receptor and methods for treating, preventing or ameliorating pain using such fusion proteins
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Application No.: US16416435Application Date: 2019-05-20
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Publication No.: US11248219B2Publication Date: 2022-02-15
- Inventor: Peter James , Keith Foster , John Chaddock , Roger Aoki , Lance Steward , Joseph Francis
- Applicant: IPSEN BIOINNOVATION LIMITED , ALLERGAN, INC.
- Applicant Address: GB Abingdon; US CA Irvine
- Assignee: IPSEN BIOINNOVATION LIMITED,ALLERGAN, INC.
- Current Assignee: IPSEN BIOINNOVATION LIMITED,ALLERGAN, INC.
- Current Assignee Address: GB Abingdon; US CA Irvine
- Agency: Barnes & Thornburg LLP
- Agent Gene J. Yao
- Main IPC: C12N9/52
- IPC: C12N9/52 ; A61K47/65 ; A61K38/00 ; C07K14/575 ; A61K47/64 ; C12N15/62
Abstract:
Single chain polypeptide fusion protein, comprising: a non-cytotoxic protease capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin targeting moiety; a protease cleavage site; a translocation domain; a first spacer located between the non-cytotoxic protease and the protease cleavage site; and a second spacer located between the galanin targeting moiety and the translocation domain.
Public/Granted literature
- US20190309277A1 FUSION PROTEINS AND METHODS FOR TREATING, PREVENTING OR AMELIORATING PAIN Public/Granted day:2019-10-10
Information query
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