Invention Grant
- Patent Title: NLRP3 inflammasome inhibitors
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Application No.: US16874905Application Date: 2020-05-15
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Publication No.: US11254653B2Publication Date: 2022-02-22
- Inventor: Christopher Farady , Nina Gommermann , Philipp Janser , Angela Mackay , Henri Mattes , Nichola Smith , Catherine Fooks Solovay , Nikolaus Johannes Stiefl , Eric Vangrevelinghe , Juraj Velcicky , Anette von Matt
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Asha K. Nadipuram
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D237/14 ; C07D237/20 ; C07D403/12 ; C07D413/12 ; C07D451/04
Abstract:
The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
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